Commanders picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine. 49ers odds via the SportsLine consensus list San Francisco as a 14-point road favorite while the over-under is at 49.5. ET, and the game will be played at FedEx Field in Landover, Md.

However, these two teams have split their last four head-to-head matchups dating back to 2017, and the Commanders would love nothing more than to steal a win and spoil San Francisco's postseason home-field aspirations. Washington hasn't won a game since the first week of November and hasn't won a game at home since the first week of the season against the Arizona Cardinals. The San Francisco 49ers (11-4) will travel to take on the Washington Commanders (4-11) on Sunday, and San Francisco will be looking to put a blowout loss at the hands of the Ravens aside.